Naloxone has saved the lives of countless individuals who were experiencing an overdose of opioids. What happens when Narcan doesn’t work on an individual who experiences an overdose? Naloxone is ineffective for individuals who are experiencing an overdose of xylazine, an animal tranquilizer detected in over 90% of drug samples in Philadelphia. Toxicology reports and other exams don’t check for xylazine. Some providers may not know about the drug either. Nonetheless, traces of xylazine are popping up nationwide, and providers must know what to do if they encounter someone who has taken drugs laced with xylazine.
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